NAD+ Reconstitution Calculator
A coenzyme central to cellular energy metabolism and DNA repair. Available as compounded injectable from licensed pharmacies.
Informational only. Not medical advice. Consult a licensed healthcare provider before starting, changing, or stopping any protocol.
NAD+
About NAD+
Not FDA-approved as a finished product. Available as a compounded preparation from licensed 503A/503B pharmacies in some U.S. states. Regulatory status evolving.
NAD+ (nicotinamide adenine dinucleotide) is a naturally occurring coenzyme present in every living cell. It serves as a central cofactor in redox reactions (energy metabolism via the electron transport chain), DNA repair (via PARP enzymes), and cellular signaling (via sirtuins and CD38). NAD+ levels decline with age in many tissues; preclinical research has explored supplementation strategies via precursors (NMN, NR) or direct NAD+ administration.
Injectable NAD+ is available as a compounded preparation from licensed 503A/503B pharmacies for clinical use. Typical subcutaneous dosing logged by users is 100–200 mg (100,000–200,000 mcg) daily or five times weekly during an 8+ week cycle. Intravenous administration (at higher doses, 250–750 mg per session) is also tracked but is typically done in clinical settings.
**Dose unit note:** NAD+ doses are larger than peptide doses — often reported in mg rather than mcg. This calculator accepts mcg input (100 mg = 100,000 mcg). The calculator's large-dose warnings handle the typical "500,000 mcg" entries without error.
Frequently asked questions
- Why are NAD+ doses so much higher than peptide doses?
- NAD+ is a small-molecule coenzyme, not a signaling peptide. Peptides like BPC-157 act at receptor-mediated sites at nanomolar concentrations — hundreds of mcg suffice. NAD+ acts as a bulk metabolic cofactor — hundreds of thousands of mcg (hundreds of mg) are typical doses.
- Is NAD+ the same as NMN or NR?
- No. NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) are NAD+ precursors — they're converted to NAD+ in the body. NMN and NR are typically oral supplements; injectable NAD+ delivers the coenzyme directly.
- What about the "flush" sensation?
- Many users report a flushing / warming / chest tightness sensation in the first 10–20 minutes after NAD+ injection, especially at higher doses. Slow administration (slow push, SC) is commonly logged as a mitigation. The notes field per dose is where users track this.
Sources
- Rajman L, et al. "Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence." Cell Metab. 2018. PMID: 29514064
- Yoshino J, et al. "NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR in Humans." Cell Metab. 2018. PMID: 29262375
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