CJC-1295 Reconstitution Calculator
A short-acting GHRH analog (also called Modified GRF 1-29). The "no DAC" variant has a very short half-life for pulsatile dosing.
Informational only. Not medical advice. Consult a licensed healthcare provider before starting, changing, or stopping any protocol.
CJC-1295 (no DAC)
About CJC-1295 (no DAC)
Not FDA-approved. Sold as a research chemical. Regulatory status varies by jurisdiction. Users are responsible for legal compliance.
CJC-1295 without DAC (also known as Modified GRF 1-29 or Mod GRF 1-29) is a synthetic modification of the first 29 amino acids of natural GHRH. The modifications stabilize the peptide against enzymatic degradation while preserving the short half-life native GHRH has in vivo — approximately 30 minutes for the no-DAC form. This is the distinguishing feature vs. the with-DAC variant (see next entry).
Users log CJC-1295 (no DAC) most commonly in combination with ipamorelin, at 100 mcg per injection, matched to ipamorelin's 2–3 times daily schedule. The short half-life is intentional — it creates a brief pulse rather than sustained elevation, which some users prefer for its closer match to endogenous GH secretion rhythm.
Frequently asked questions
- What does "DAC" mean?
- DAC = Drug Affinity Complex. The with-DAC variant includes a chemical modification that binds the peptide to serum albumin, extending half-life to ~8 days. The no-DAC variant omits this modification, keeping the half-life at ~30 minutes.
- Which variant should I use?
- This app doesn't recommend one over the other — it tracks whichever you're using. Users tracking pulsatile protocols (e.g., with ipamorelin) typically choose no-DAC. Users tracking sustained plateau protocols choose with-DAC. Both variants have their own SEO page and calculator preset.
- What's a typical dose?
- 100 mcg per injection is the most commonly logged dose for no-DAC, matched to ipamorelin's schedule. Some users log up to 200 mcg. The calculator above accepts your specific values.
Sources
- Teichman SL, et al. "Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295." J Clin Endocrinol Metab. 2006. (with-DAC reference; contrasts with no-DAC kinetics) PMID: 16507636
About CJC-1295 (with DAC)
Not FDA-approved. Sold as a research chemical. Regulatory status varies by jurisdiction. Users are responsible for legal compliance.
CJC-1295 with DAC adds a Drug Affinity Complex (DAC) modification — specifically a maleimidopropionic acid group — that covalently binds the peptide to serum albumin after injection. This extends half-life dramatically, from ~30 minutes (no-DAC) to ~8 days (with-DAC). The result is sustained GHRH receptor stimulation rather than pulsatile pulses.
Users tracking the with-DAC variant typically log 1,000–2,000 mcg per injection, twice weekly or once weekly. The sustained plateau differs mechanistically from the pulsatile approach of no-DAC + ipamorelin. Neither is recommended over the other — users track whichever matches their protocol design.
Frequently asked questions
- Why such a huge difference in dose between with-DAC and no-DAC?
- Different PK profiles support different dosing strategies. No-DAC's short half-life means frequent small doses. With-DAC's long half-life means infrequent larger doses. Total weekly exposure can be similar at different dose/frequency combinations.
- Can I stack with-DAC alongside ipamorelin?
- Users log this combination; the sustained GHRH stimulation from with-DAC provides a background "baseline" of receptor activation, while pulsatile ipamorelin adds GHRP-class activation. Whether this is "better" or just "different" from no-DAC + ipamorelin is a research literature question outside this app's scope.
- Is with-DAC FDA-approved?
- No. Like no-DAC, with-DAC is classified as a research chemical. Regulatory status varies by jurisdiction.
Sources
- Teichman SL, et al. "Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults." J Clin Endocrinol Metab. 2006. PMID: 16507636
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